17,20β-Dihydroxy-4-pregnen-3-one

Yukiko Ogino, Shinichi Miyagawa, Taisen Iguchi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DP), also known as a maturation-inducing hormone (MIH), is required for the meiotic maturation of oocytes and sperm maturation in teleost fish. It is produced in the ovarian follicle from the precursor, 17α-hydroxyprogesterone, by the enzyme 20β-hydroxysteroid dehydrogenase. The 17α,20β-DP acts via its receptor, 17α,20β-DPR, on the plasma membrane of oocytes. It also has a nuclear receptor-mediated action in the testis of the Japanese eel.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
PublisherElsevier
Pages509-510
Number of pages2
ISBN (Electronic)9780128010280
ISBN (Print)9780128010679
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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