1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Sei Joon Jeong; Masanori Inagaki; Ryuichi Higuchi; Tomofumi Miyamoto; Mayumi Ono; Michihiko Kuwano; Rob W.M. Van Soest

doi:10.1248/cpb.51.731

1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Sei Joon Jeong, Masanori Inagaki, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Rob W.M. Van Soest

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

Original language	English
Pages (from-to)	731-733
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	51
Issue number	6
DOIs	https://doi.org/10.1248/cpb.51.731
Publication status	Published - Jun 2003

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.51.731

Cite this

@article{48e2a357790f4855b133355e9126e880,

title = "1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis",

abstract = "An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.",

author = "Jeong, {Sei Joon} and Masanori Inagaki and Ryuichi Higuchi and Tomofumi Miyamoto and Mayumi Ono and Michihiko Kuwano and {Van Soest}, {Rob W.M.}",

year = "2003",

month = jun,

doi = "10.1248/cpb.51.731",

language = "English",

volume = "51",

pages = "731--733",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "The Pharmaceutical Society of Japan",

number = "6",

}

TY - JOUR

T1 - 1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

AU - Jeong, Sei Joon

AU - Inagaki, Masanori

AU - Higuchi, Ryuichi

AU - Miyamoto, Tomofumi

AU - Ono, Mayumi

AU - Kuwano, Michihiko

AU - Van Soest, Rob W.M.

PY - 2003/6

Y1 - 2003/6

N2 - An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

AB - An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

UR - http://www.scopus.com/inward/record.url?scp=12344312135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12344312135&partnerID=8YFLogxK

U2 - 10.1248/cpb.51.731

DO - 10.1248/cpb.51.731

M3 - Article

C2 - 12808256

AN - SCOPUS:12344312135

SN - 0009-2363

VL - 51

SP - 731

EP - 733

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 6

ER -

1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this