1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Sei Joon Jeong, Masanori Inagaki, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Rob W.M. Van Soest

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

Original languageEnglish
Pages (from-to)731-733
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number6
Publication statusPublished - Jun 2003

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery


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