1-Hexylcarbamoyl-5-fluorouracil alters the expression of heat shock protein in HeLa cells.

T. Kusumoto, Y. Maehara, Y. Sakaguchi, Y. Emi, S. Kohnoe, K. Sugimachi

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3 Citations (Scopus)


We determined the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a masked compound of 5-fluorouracil, on the expression of heat shock protein (HSP) in heat-treated HeLa cells. We used a monoclonal anti-72-kDa heat shock protein antibody. At 37 degrees C, HSP was predominant in the cytoplasm of cells and heating to 43 degrees C for 30 min increased the synthesis of HSP in the nucleus. When HeLa cells were treated with heat and HCFU, at a concentration which showed evidence of synergy, nuclear staining of the cells decreased. Thus, the altered expression of HSP by HCFU is related to a synergism between heat and HCFU.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalAnti-cancer drugs
Issue number1
Publication statusPublished - Feb 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research


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