TY - JOUR
T1 - γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein
AU - Yamashita, Shuya
AU - Baba, Kiwako
AU - Makio, Akiko
AU - Kumazoe, Motofumi
AU - Huang, Yuhui
AU - Lin, I. Chian
AU - Bae, Jaehoon
AU - Murata, Motoki
AU - Yamada, Shuhei
AU - Tachibana, Hirofumi
N1 - Funding Information:
This work was supported in part by the Japan Society for the Promotion of Science KAKENHI grant 22228002 and 15H02448 to H. Tachibana. We appreciate the grant supports from the Project of the NARO Bio-oriented Technology Research Advancement Institution (Integration research for agriculture and interdisciplinary fields).
Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
PY - 2016/5/13
Y1 - 2016/5/13
N2 - Previous studies have identified biomolecules that mediate the physiological actions of food factors, such as amino acids, vitamins, fatty acids, minerals, plant polyphenols, and lactobacilli, suggesting that our bodies are equipped with an innate system that senses which food factors are required to maintain our health. However, the effects of environmental factors on food factor sensing (FFS) remains largely unknown. Tocotorienols (T3s), which belongs to the vitamin E family, possess several physiological functions, including cholesterol lowering and neuroprotective effects. Here, we investigated the effects of naturally abundant γ-T3 on FFS-related gene expressions in melanoma using a DNA chip. Our results showed that γ-T3 increased the expression level of aryl hydrocarbon receptor (AhR), a sensing molecule to plant polyphenol baicalein. The co-treatment with γ-T3 and baicalein enhanced the anti-proliferative activity of baicalein, accompanied by the downstream events of AhR-activation induced by baicalein. These data suggest that γ-T3 upregulates AhR expression and enhances its sensitivity to baicalein.
AB - Previous studies have identified biomolecules that mediate the physiological actions of food factors, such as amino acids, vitamins, fatty acids, minerals, plant polyphenols, and lactobacilli, suggesting that our bodies are equipped with an innate system that senses which food factors are required to maintain our health. However, the effects of environmental factors on food factor sensing (FFS) remains largely unknown. Tocotorienols (T3s), which belongs to the vitamin E family, possess several physiological functions, including cholesterol lowering and neuroprotective effects. Here, we investigated the effects of naturally abundant γ-T3 on FFS-related gene expressions in melanoma using a DNA chip. Our results showed that γ-T3 increased the expression level of aryl hydrocarbon receptor (AhR), a sensing molecule to plant polyphenol baicalein. The co-treatment with γ-T3 and baicalein enhanced the anti-proliferative activity of baicalein, accompanied by the downstream events of AhR-activation induced by baicalein. These data suggest that γ-T3 upregulates AhR expression and enhances its sensitivity to baicalein.
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U2 - 10.1016/j.bbrc.2016.03.111
DO - 10.1016/j.bbrc.2016.03.111
M3 - Article
C2 - 27055589
AN - SCOPUS:84964963548
SN - 0006-291X
VL - 473
SP - 801
EP - 807
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -