TY - JOUR
T1 - α2 integrin +807 polymorphism in drug-induced gingival overgrowth
AU - Ogino, M.
AU - Kido, J.
AU - Bando, M.
AU - Hayashi, N.
AU - Wada, C.
AU - Nagata, T.
AU - Nishimura, F.
AU - Soga, Y.
AU - Takashiba, S.
AU - Kubota, T.
AU - Itagaki, M.
AU - Shimada, Y.
AU - Tai, H.
AU - Yoshie, H.
AU - Yamazaki, N.
AU - Shinohara, Y.
AU - Kataoka, M.
PY - 2005/12
Y1 - 2005/12
N2 - α2 integrin on fibroblasts is reported to play an important role in the induction of drug-induced gingival overgrowth, which is characterized by excessive accumulation of type I collagen in gingival connective tissue. Silent polymorphism 807 T/C within the α2 integrin gene is associated with high/low α2 integrin expression. The aim of this study was to test the hypothesis that expression of α2 integrin 807 T/C polymorphism correlates with drug-induced gingival overgrowth. A case-control study comparing 136 subjects taking calcium channel blockers (72 with vs. 64 without drug-induced gingival overgrowth) demonstrated that the frequency of the +807 C allele was significantly higher in the case group than in the controls (odds ratio, 3.61; 95% confidence interval, 2.14 - 6.10; P < 0.05). The present findings suggest that the α2 +807 C allele is one of the genetic risk factors for drug-induced gingival overgrowth.
AB - α2 integrin on fibroblasts is reported to play an important role in the induction of drug-induced gingival overgrowth, which is characterized by excessive accumulation of type I collagen in gingival connective tissue. Silent polymorphism 807 T/C within the α2 integrin gene is associated with high/low α2 integrin expression. The aim of this study was to test the hypothesis that expression of α2 integrin 807 T/C polymorphism correlates with drug-induced gingival overgrowth. A case-control study comparing 136 subjects taking calcium channel blockers (72 with vs. 64 without drug-induced gingival overgrowth) demonstrated that the frequency of the +807 C allele was significantly higher in the case group than in the controls (odds ratio, 3.61; 95% confidence interval, 2.14 - 6.10; P < 0.05). The present findings suggest that the α2 +807 C allele is one of the genetic risk factors for drug-induced gingival overgrowth.
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U2 - 10.1177/154405910508401217
DO - 10.1177/154405910508401217
M3 - Article
C2 - 16304451
AN - SCOPUS:33644813348
SN - 0022-0345
VL - 84
SP - 1183
EP - 1186
JO - Journal of Dental Research
JF - Journal of Dental Research
IS - 12
ER -