α-Glucosidase inhibitory profile of Nigerian medicinal plants in immobilized assay system

Isiaka Ajani Ogunwande; Toshiro Matsui; Tomoko Fujise; Kiyoshi Matsumoto

doi:10.3136/fstr.13.169

α-Glucosidase inhibitory profile of Nigerian medicinal plants in immobilized assay system

Isiaka Ajani Ogunwande, Toshiro Matsui, Tomoko Fujise, Kiyoshi Matsumoto

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Four Nigerian medicinal plants used for the treatment of various ailments in traditional ethnomedicine were evaluated for their anti-diabetic potential. The plants Irvingia gabonensis (O'Rorke) Bail, Eucalyptus torreliana F.v. Muell, Securidata longependuculata Fers and Murraya panicutata (L.) Jack were used in the study. Only the aqueous extract of I. gabonensis exhibited a potent maltase-inhibitory activity with an IC₅₀ of O.10mg/mL, as well as a sucrase-inhibitory activity (IC₅₀ of O.llmg/mL), whereas α-amylase inhibitory activity was quite poor (IC₅₀ of 0.53 mg/mL). A significant lowering of the blood glycemie response to maltose ingestion in 8-week old Sprague-Dawley rats was observed at a dose of 300 mg/kg, in response to significant reduction in postprandial insulin response level.

Original language	English
Pages (from-to)	169-172
Number of pages	4
Journal	Food Science and Technology Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.3136/fstr.13.169
Publication status	Published - May 1 2007

All Science Journal Classification (ASJC) codes

Biotechnology
Food Science
Chemical Engineering(all)
Industrial and Manufacturing Engineering
Marketing

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10.3136/fstr.13.169

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abstract = "Four Nigerian medicinal plants used for the treatment of various ailments in traditional ethnomedicine were evaluated for their anti-diabetic potential. The plants Irvingia gabonensis (O'Rorke) Bail, Eucalyptus torreliana F.v. Muell, Securidata longependuculata Fers and Murraya panicutata (L.) Jack were used in the study. Only the aqueous extract of I. gabonensis exhibited a potent maltase-inhibitory activity with an IC50 of O.10mg/mL, as well as a sucrase-inhibitory activity (IC50 of O.llmg/mL), whereas α-amylase inhibitory activity was quite poor (IC50 of 0.53 mg/mL). A significant lowering of the blood glycemie response to maltose ingestion in 8-week old Sprague-Dawley rats was observed at a dose of 300 mg/kg, in response to significant reduction in postprandial insulin response level.",

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AU - Ogunwande, Isiaka Ajani

AU - Matsui, Toshiro

AU - Fujise, Tomoko

AU - Matsumoto, Kiyoshi

PY - 2007/5/1

Y1 - 2007/5/1

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α-Glucosidase inhibitory profile of Nigerian medicinal plants in immobilized assay system

Abstract

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UN SDGs

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