Research Center for Precision Medicine

Research output

Research output per year 2014 2021 2022 2023 2024 2025

• 37 Article
• 3 Letter
• 1 Comment/debate
• 1 Editorial

Research output per year

Research output per year

Search results

• 2025

  TIM-3 marks measurable residual leukemic stem cells responsible for relapse after allogeneic stem cell transplantation

  Sakoda, T., Kikushige, Y., Irifune, H., Kawano, G., Harada, T., Semba, Y., Hayashi, M., Shima, T., Mori, Y., Eto, T., Kamimura, T., Iwasaki, H., Ogawa, R., Yoshimoto, G., Kato, K., Maeda, T., Miyamoto, T. & Akashi, K., Mar 2025, In: Cancer Science. 116, 3, p. 698-709 12 p.

  Research output: Contribution to journal › Article › peer-review

  • T Cell 100%
  • Immunoglobulin 100%
  • Stem Cell 100%
  • Allogeneic Stem Cell Transplantation 100%
  • Mucin 3 100%
• 2024

  A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence

  Sunami, K., Naito, Y., Saigusa, Y., Amano, T., Ennishi, D., Imai, M., Kage, H., Kanai, M., Kenmotsu, H., Komine, K., Koyama, T., Maeda, T., Morita, S., Sakai, D., Hirata, M., Ito, M., Kozuki, T., Sakashita, H., Horinouchi, H. & Okuma, Y. & 15 others, Takashima, A., Kubo, T., Hironaka, S., Segawa, Y., Yakushijin, Y., Bando, H., Makiyama, A., Suzuki, T., Kinoshita, I., Kohsaka, S., Ohe, Y., Ishioka, C., Yamamoto, K., Tsuchihara, K. & Yoshino, T., Jan 18 2024, In: JAMA Oncology. 10, 1, p. 95-102 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Artificial Intelligence 100%
  • Accreditation 28%
  • Clinical Utility 14%
  7 Citations (Scopus)

• Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia

  Yanagiya, R., Miyatake, Y., Watanabe, N., Shimizu, T., Kanamori, A., Ueno, M., Okabe, S., Carreras, J., Nakayama, S., Hasegawa, A., Kameda, K., Kamakura, T., Nakagawa, S., Yamauchi, T., Maeda, T., Ishii, K., Matsuura, T., Handa, H., Hirao, A. & Ishizawa, K. & 5 others, Onizuka, M., Mashima, T., Nakamura, N., Ando, K. & Kotani, A., Aug 2024, In: Leukemia. 38, 8, p. 1731-1741 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amino Acid 100%
  • Aggressive NK Cell Leukemia 100%
  • Leukemia Cell 75%
  • Liver Sinusoid 25%
  • CD71 Antigen 25%
  1 Citation (Scopus)

• A prospective, multicenter, observational study of ixazomib plus lenalidomide-dexamethasone in patients with relapsed/refractory multiple myeloma in Japan

  Horigome, Y., Iino, M., Harazaki, Y., Kobayashi, T., Handa, H., Hiramatsu, Y., Kuroi, T., Tanimoto, K., Matsue, K., Abe, M., Ishida, T., Ito, S., Iwasaki, H., Kuroda, J., Shibayama, H., Sunami, K., Takamatsu, H., Tamura, H., Hayashi, T. & Akagi, K. & 5 others, Maeda, T., Yoshida, T., Mori, I., Shinozaki, T. & Iida, S., Feb 2024, In: Annals of Hematology. 103, 2, p. 475-488 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Progression Free Survival 100%
  • Dexamethasone 100%
  • Multiple Myeloma 100%
  • Observational Study 100%
  • Lenalidomide 100%
  3 Citations (Scopus)

• ctDNA improves prognostic prediction for patients with relapsed/refractory MM receiving ixazomib, lenalidomide, and dexamethasone

  Kogure, Y., Handa, H., Ito, Y., Ri, M., Horigome, Y., Iino, M., Harazaki, Y., Kobayashi, T., Abe, M., Ishida, T., Ito, S., Iwasaki, H., Kuroda, J., Shibayama, H., Sunami, K., Takamatsu, H., Tamura, H., Hayashi, T., Akagi, K. & Shinozaki, T. & 5 others, Yoshida, T., Mori, I., Iida, S., Maeda, T. & Kataoka, K., Jun 6 2024, In: Blood. 143, 23, p. 2401-2413 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dexamethasone 100%
  • Circulating Tumor DNA 100%
  • DNA Mutation 45%
  • Plasma Cell 45%
  • KRAS 36%
  7 Citations (Scopus)

• Epstein-Barr virus monitoring for preemptive re-hematopoietic cell transplantation in CD3δ-deficient siblings

  Park, S., Sonoda, M., Eguchi, K., Adachi, S., Kinoshita, K., Semba, Y., Ishimura, M. & Ohga, S., Aug 2024, In: Medical and Pediatric Oncology. 71, 8, p. e31119

  Research output: Contribution to journal › Article › peer-review

• Epstein–Barr virus monitoring for preemptive re-hematopoietic cell transplantation in CD3δ-deficient siblings

  Park, S., Sonoda, M., Eguchi, K., Adachi, S., Kinoshita, K., Semba, Y., Ishimura, M. & Ohga, S., 2024, (Accepted/In press) In: Pediatric Blood and Cancer. 71, 8, e31119.

  Research output: Contribution to journal › Letter › peer-review
• 2023

  A preterm newborn-onset juvenile myelomonocytic leukemia-like myeloproliferation with PTPN11 mutation

  Yamamoto, S., Nakao, S., Inoue, H., Koga, Y., Kojima-Ishii, K., Semba, Y., Maeda, T., Akashi, K. & Ohga, S., Feb 2023, In: Pediatric Blood and Cancer. 70, 2, e29915.

  Research output: Contribution to journal › Letter › peer-review

• CELMoD for ALL: an exciting prospect

  Maeda, T., Aug 17 2023, In: Blood. 142, 7, p. 614-615 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
  1 Citation (Scopus)

• Co-stimulatory and immune checkpoint molecules are important in the tumor microenvironment of Hodgkin-like adult T-cell leukemia/lymphoma

  Takeuchi, M., Miyoshi, H., Semba, Y., Yamada, K., Nakashima, K., Sato, K., Furuta, T., Moritsubo, M., Ogura, Y., Tanaka, K., Imamoto, T., Arakawa, F., Kohno, K. & Ohshima, K., Dec 2023, In: Haematologica. 108, 12, p. 3496-3501 6 p.

  Research output: Contribution to journal › Letter › peer-review

• Digital spatial profiling of CD4⁺ T cells in classic Hodgkin lymphoma

  Takeuchi, M., Miyoshi, H., Semba, Y., Yamada, K., Nakashima, K., Sato, K., Furuta, T., Moritsubo, M., Ogura, Y., Tanaka, K., Imamoto, T., Arakawa, F., Kohno, K. & Ohshima, K., Aug 2023, In: Virchows Archiv. 483, 2, p. 255-260 6 p.

  Research output: Contribution to journal › Article › peer-review

  • T-Helper Cell 100%
  • Classical Hodgkin Lymphoma 100%
  • Rosette Formation 60%
  • Reed-Sternberg Cell 40%
  • Protein 20%
  5 Citations (Scopus)

• MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins

  Komata, Y., Kanai, A., Maeda, T., Inaba, T. & Yokoyama, A., Dec 2023, In: Nature communications. 14, 1, 1979.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fusion Protein 100%
  • DOT1L 100%
  • Chromatin 33%
  • Lysine 33%
  • Chromosomal Translocation 33%
  4 Citations (Scopus)

• POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis

  Nakashima, K., Kunisaki, Y., Hosokawa, K., Gotou, K., Yao, H., Yuta, R., Semba, Y., Nogami, J., Kikushige, Y., Stumpf, P. S., MacArthur, B. D., Kang, D., Akashi, K., Ohga, S. & Arai, F., Dec 2023, In: Communications Biology. 6, 1, 996.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lymphopoiesis 100%
  • Telomere 100%
  • Stem Cell 55%
  • Mesenchymal Stem Cell 55%
  • Bone 44%
  1 Citation (Scopus)

• RHAMM marks proliferative subpopulation of human colorectal cancer stem cells

  Nakano, M., Taguchi, R., Kikushige, Y., Isobe, T., Miyawaki, K., Mizuno, S., Tsuruta, N., Hanamura, F., Yamaguchi, K., Yamauchi, T., ariyama, H., Kusaba, H., Nakamura, M., Maeda, T., Kuo, C. J., Baba, E. & Akashi, K., Jul 2023, In: Cancer Science. 114, 7, p. 2895-2906 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptor 100%
  • Restylane 100%
  • Hyaluronan 100%
  • Hyaluronic Acid 100%
  • Cancer Stem Cell 66%
  6 Citations (Scopus)

• Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance

  Nakao, F., Setoguchi, K., Semba, Y., Yamauchi, T., Nogami, J., Sasaki, K., Imanaga, H., Terasaki, T., Miyazaki, M., Hirabayashi, S., Miyawaki, K., Kikushige, Y., Masuda, T., Akashi, K. & Maeda, T., May 2023, In: Leukemia. 37, 5, p. 1028-1038 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apoptosis 100%
  • Mouse 33%
  • Contrast 33%
  • Molecule 33%
  • Ligase 33%
  11 Citations (Scopus)
• 2022

  A germinal center–associated microenvironmental signature reflects malignant phenotype and outcome of DLBCL

  Miyawaki, K., Kato, K., Sugio, T., Sasaki, K., Miyoshi, H., Semba, Y., Kikushige, Y., Mori, Y., Kunisaki, Y., Iwasaki, H., Miyamoto, T., Kuo, F. C., Aster, J. C., Ohshima, K., Maeda, T. & Akashi, K., Apr 12 2022, In: Blood Advances. 6, 7, p. 2388-2402 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diffuse Large B-Cell Lymphoma 100%
  • Cells 66%
  • Germinal Center 66%
  • Prognosis 50%
  • Tissues 50%
  11 Citations (Scopus)

• Chronological improvement in precision oncology implementation in Japan

  Sunami, K., Naito, Y., Komine, K., Amano, T., Ennishi, D., Imai, M., Kage, H., Kanai, M., Kenmotsu, H., Koyama, T., Maeda, T., Morita, S., Sakai, D., Kohsaka, S., Tsuchihara, K., Saigusa, Y. & Yoshino, T., Nov 2022, In: Cancer Science. 113, 11, p. 3995-4000 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm 100%
  • Hospital 100%
  • Therapeutic Procedure 60%
  • Genetic Counseling 60%
  • Patient 40%
  20 Citations (Scopus)

• Concordance Between Recommendations From Multidisciplinary Molecular Tumor Boards and Central Consensus for Cancer Treatment in Japan

  Naito, Y., Sunami, K., Kage, H., Komine, K., Amano, T., Imai, M., Koyama, T., Ennishi, D., Kanai, M., Kenmotsu, H., Maeda, T., Morita, S., Sakai, D., Watanabe, K., Shirota, H., Kinoshita, I., Yoshioka, M., Mamesaya, N., Ito, M. & Kohsaka, S. & 5 others, Saigusa, Y., Yamamoto, K., Hirata, M., Tsuchihara, K. & Yoshino, T., Dec 5 2022, In: JAMA network open. 5, 12, e2245081.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Therapeutic Procedure 100%
  • Neoplasm 83%
  • Consensus 58%
  • Malignant Neoplasm 41%
  • Patient 16%
  12 Citations (Scopus)

• Expert panel consensus recommendations on the use of circulating tumor DNA assays for patients with advanced solid tumors

  Imai, M., Nakamura, Y., Sunami, K., Kage, H., Komine, K., Koyama, T., Amano, T., Ennishi, D., Kanai, M., Kenmotsu, H., Maeda, T., Morita, S., Sakai, D., Bando, H., Makiyama, A., Suzuki, T., Hirata, M., Kohsaka, S., Tsuchihara, K. & Naito, Y. & 1 others, Yoshino, T., Nov 2022, In: Cancer Science. 113, 11, p. 3646-3656 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Consensus 100%
  • Solid Malignant Neoplasm 100%
  • DNA Determination 100%
  • Circulating Tumor DNA 100%
  8 Citations (Scopus)

• Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL

  Sasaki, K., Yamauchi, T., Semba, Y., Nogami, J., Imanaga, H., Terasaki, T., Nakao, F., Akahane, K., Inukai, T., Verhoeyen, E., Akashi, K. & Maeda, T., Feb 3 2022, In: Blood. 139, 5, p. 748-760 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Lymphoblastic Leukemia 100%
  • CRLF2 100%
  • Ruxolitinib 55%
  • Leukemia Cell 33%
  • Cells 22%
  13 Citations (Scopus)

• Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions

  Ito, M., Nakano, M., Ariyama, H., Yamaguchi, K., Tanaka, R., Semba, Y., Sugio, T., Miyawaki, K., Kikushige, Y., Mizuno, S., Isobe, T., Tanoue, K., Taguchi, R., Ueno, S., Kawano, T., Murata, M., Baba, E. & Akashi, K., Feb 10 2022, (E-pub ahead of print) In: Cancer Letters. 532, p. 215597

  Research output: Contribution to journal › Article › peer-review

  • Fibroblast 100%
  • Cancer Associated Fibroblast 80%
  • Macrophage 80%
  • Cells 80%
  • Cancer Cell 40%
  13 Citations (Scopus)

• Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC

  Swartzel, J. C., Bond, M. J., Pintado-Urbanc, A. P., Daftary, M., Krone, M. W., Douglas, T., Carder, E. J., Zimmer, J. T., Maeda, T., Simon, M. D. & Crews, C. M., Jul 15 2022, In: ACS Chemical Biology. 17, 7, p. 1789-1798 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Degradation 100%
  • Messenger RNA 100%
  • Lysozyme 100%
  • Myeloid 100%
  • RNA 33%
  4 Citations (Scopus)

• TET2 Clonal Hematopoiesis Is Associated With Anthracycline-Induced Cardiotoxicity in Patients With Lymphoma

  Hatakeyama, K., Hieda, M., Semba, Y., Moriyama, S., Wang, Y., Maeda, T., Kato, K., Miyamoto, T., Akashi, K. & Kikushige, Y., Mar 2022, In: JACC: CardioOncology. 4, 1, p. 141-143 3 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)
• 2021

  A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of DLBCL

  Miyawaki, K., Kato, K., Sugio, T., Sasaki, K., Miyoshi, H., Semba, Y., Kikushige, Y., Mori, Y., Kunisaki, Y., Iwasaki, H., Miyamoto, T., Kuo, F. C., Aster, J. C., Ohshima, K., Maeda, T. & Akashi, K., Oct 12 2021, (E-pub ahead of print) In: Blood Advances.

  Research output: Contribution to journal › Article › peer-review

  • Diffuse Large B-Cell Lymphoma 100%
  • Germinal Center 83%
  • Cells 66%
  • Prognosis 50%
  • Tissues 50%

• Beneficial tyrosine kinase inhibitor therapy in a patient with relapsed BCR-ABL1-like acute lymphoblastic leukemia with CCDC88C-PDGFRB fusion

  Oya, S., Morishige, S., Ozawa, H., Sasaki, K., Semba, Y., Yamasaki, Y., Nakamura, T., Aoyama, K., Seki, R., Mouri, F., Osaki, K., Miyamoto, T., Maeda, T. & Nagafuji, K., Feb 2021, In: International journal of hematology. 113, 2, p. 285-289 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Lymphoblastic Leukemia 100%
  • Combination Therapy 83%
  • Spontaneous Remission 50%
  • Clinical Trial 50%
  • Imatinib 33%
  2 Citations (Scopus)

• Clinical features and chromosomal/genetic aberration in adult acute lymphoblastic leukemia in Japan: results of Fukuoka Blood & Marrow Transplant Group Studies ALL MRD 2002 and 2008

  Morishige, S., Miyamoto, T., Eto, T., Uchida, N., Kamimura, T., Miyazaki, Y., Ogawa, R., Okumura, H., Fujisak, T., Iwasaki, H., Kawano, N., Wake, A., Ohta, T., Takamatsu, Y., Kurokawa, T., Ito, Y., Maeda, T., Akashi, K. & Nagafuji, K., Jun 2021, In: International journal of hematology. 113, 6, p. 815-822 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Lymphoblastic Leukemia 100%
  • Adult 45%
  • Age 36%
  • Lineages 27%
  • Prevalence 18%
  3 Citations (Scopus)

• Correction to: The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan (International Journal of Clinical Oncology, (2021), 26, 3, (443-449), 10.1007/s10147-020-01844-1)

  Sunami, K., Naito, Y., Aimono, E., Amano, T., Ennishi, D., Kage, H., Kanai, M., Komine, K., Koyama, T., Maeda, T., Morita, S., Sakai, D., Kohsaka, S., Tsuchihara, K. & Yoshino, T., May 2021, In: International Journal of Clinical Oncology. 26, 5, p. 1007 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Hospital 100%
  • Therapeutic Procedure 66%
  • Genetic Counseling 66%
  • Combination Therapy 33%
  • Malignant Neoplasm 33%

• Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL

  Sasaki, K., Yamauchi, T., Semba, Y., Nogami, J., Imanaga, H., Terasaki, T., Nakao, F., Akahane, K., Inukai, T., Verhoeyen, E., Akashi, K. & Maeda, T., Sept 29 2021, (E-pub ahead of print) In: Blood.

  Research output: Contribution to journal › Article › peer-review

  • Acute Lymphoblastic Leukemia 100%
  • CRLF2 100%
  • Ruxolitinib 55%
  • Leukemia Cell 33%
  • Cells 22%

• Granulocyte collection by polymorphonuclear cell-targeting apheresis with medium-molecular-weight hydroxyethyl starch

  Henzan, T., Yamauchi, T., Yamanaka, I., Sakoda, T., Semba, Y., Hayashi, M., Kikushige, Y., Mishima, H., Ishimura, M., Koga, Y., Miyamoto, T., Ohga, S., Akashi, K., Maeda, T. & Kunisaki, Y., Dec 2021, In: International journal of hematology. 114, 6, p. 691-700 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Weight 100%
  • Hydroxyethyl Starch 100%
  • Granulocyte 81%
  • Apheresis 54%
  • Donor 27%
  2 Citations (Scopus)

• Outcome predictors after retransplantation in relapsed acute lymphoblastic leukemia: a multicenter, retrospective study

  Fukuoka Blood and Marrow Transplantation Group, Jan 2021, In: Annals of Hematology. 100, 1, p. 197-208 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Lymphoblastic Leukemia 100%
  • Patient 75%
  • Retrospective Study 50%
  • Relapse 37%
  • Hematopoietic Cell 37%
  4 Citations (Scopus)

• Platelet decrease and efficacy of platelet-rich plasma return following peripheral blood stem cell apheresis

  Shima, T., Sakoda, T., Henzan, T., Kunisaki, Y., Sugio, T., Kamezaki, K., Iwasaki, H., Teshima, T., Maeda, T., Akashi, K. & Miyamoto, T., Oct 2021, In: Journal of Clinical Apheresis. 36, 5, p. 687-696 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Platelet 100%
  • Peripheral Blood Stem Cell 61%
  • Apheresis 53%
  • Thrombocyte Rich Plasma 46%
  • Patient 7%
  2 Citations (Scopus)

• Targeting leukemia-specific dependence on the de novo purine synthesis pathway

  Yamauchi, T., Miyawaki, K., Semba, Y., Takahashi, M., Izumi, Y., Nogami, J., Nakao, F., Sugio, T., Sasaki, K., Pinello, L., Bauer, D. E., Bamba, T., Akashi, K. & Maeda, T., 2021, (Accepted/In press) In: Leukemia. 36, 2, p. 383-393 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Myeloid 100%
  • Purine Synthesis 30%
  • CRISPR/Cas9 20%
  • Nested Gene 10%
  • Electric Potential 10%
  15 Citations (Scopus)

• The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan

  Sunami, K., Naito, Y., Aimono, E., Amano, T., Ennishi, D., Kage, H., Kanai, M., Komine, K., Koyama, T., Maeda, T., Morita, S., Sakai, D., Kohsaka, S., Tsuchihara, K. & Yoshino, T., Mar 2021, In: International Journal of Clinical Oncology. 26, 3, p. 443-449 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Malignant Neoplasm 100%
  • Therapeutic Procedure 60%
  • Hospital 60%
  • Genetic Counseling 60%
  • Accuracy 40%
  30 Citations (Scopus)
• 2020

  Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug-induced thrombocytopenia

  Tochigi, T., Miyamoto, T., Hatakeyama, K., Sakoda, T., Ishihara, D., Irifune, H., Shima, T., Kato, K., Maeda, T., Ito, T., Handa, H., Akashi, K. & Kikushige, Y., Jun 11 2020, In: Blood. 135, 24, p. 2146-2158 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aromatase 100%
  • Thrombocytopenia 83%
  • Cereblon 83%
  • Therapeutic Procedure 66%
  • Estradiol 33%
  15 Citations (Scopus)

• Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45^– TER119^–Erythroid and Lymphoid Progenitors

  Gotoh, K., Kunisaki, Y., Mizuguchi, S., Setoyama, D., Hosokawa, K., Yao, H., Nakashima, Y., Yagi, M., Uchiumi, T., Semba, Y., Nogami, J., Akashi, K., Arai, F. & Kang, D., Nov 20 2020, In: iScience. 23, 11, 101654.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cells 100%
  • Phosphorus 32 80%
  • Differentiation 60%
  • Protein Synthesis 60%
  • Mitochondrial Protein 60%
  6 Citations (Scopus)
• 2018

  Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

  Harada, A., Maehara, K., Ono, Y., Taguchi, H., Yoshioka, K., Kitajima, Y., Xie, Y., Sato, Y., Iwasaki, T., Nogami, J., Okada, S., Komatsu, T., Semba, Y., Takemoto, T., Kimura, H., Kurumizaka, H. & Ohkawa, Y., Dec 1 2018, In: Nature communications. 9, 1, 1400.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Skeletal Muscle 100%
  • Nucleosome 100%
  • Histone 75%
  • Chromatin 50%
  • Muscle Regeneration 50%
  26 Citations (Scopus)
• 2017

  Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

  Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., Sept 1 2017, In: Nucleic acids research. 45, 15, p. 8758-8772 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Embryonic Stem Cell 100%
  • Helicase 83%
  • DNA-binding Domain 83%
  • Chromodomain 83%
  • Differentiation 83%
  29 Citations (Scopus)

• Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8

  Taguchi, H., Xie, Y., Horikoshi, N., Maehara, K., Harada, A., Nogami, J., Sato, K., Arimura, Y., Osakabe, A., Kujirai, T., Iwasaki, T., Semba, Y., Tachibana, T., Kimura, H., Ohkawa, Y. & Kurumizaka, H., Apr 25 2017, In: Biochemistry. 56, 16, p. 2184-2196 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleosome 100%
  • Histone H3 42%
  • Amino Acids 28%
  • Crystal Structure 28%
  • Epigenetics 28%
  22 Citations (Scopus)

• Persistent detection of alternatively spliced BCR-ABL variant results in a failure to achieve deep molecular response

  Yuda, J., Miyamoto, T., Odawara, J., Ohkawa, Y., Semba, Y., Hayashi, M., Miyamura, K., Tanimoto, M., Yamamoto, K., Taniwaki, M. & Akashi, K., Nov 2017, In: Cancer Science. 108, 11, p. 2204-2212 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Polymerase Chain Reaction 100%
  • Tyrosine-Kinase Inhibitor 83%
  • Mutant 50%
  • Monitoring 33%
  15 Citations (Scopus)
• 2016

  Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2

  Hayashi, M., Maehara, K., Harada, A., Semba, Y., Kudo, K., Takahashi, H., Oki, S., Meno, C., Ichiyanagi, K., Akashi, K. & Ohkawa, Y., Mar 2016, In: Journal of Cellular Biochemistry. 117, 3, p. 780-792 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mouse 100%
  • Embryonic Stem Cell 100%
  • Endogenous Retrovirus 100%
  • Histone 50%
  • Spermatogenesis 50%
  28 Citations (Scopus)

• Identification of immunoglobulin gene sequences from a small read number of mRNA-seq using hybridomas

  Kuniyoshi, Y., Maehara, K., Iwasaki, T., Hayashi, M., Semba, Y., Fujita, M., Sato, Y., Kimura, H., Harada, A. & Ohkawa, Y., Oct 2016, In: PloS one. 11, 10, e0165473.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hybridoma 100%
  • Coding 50%
  • Messenger RNA 50%
  • Monospecific Antibody 33%
  • Immunoglobulin Gene 33%
  11 Citations (Scopus)
• 2014

  Generation of a monoclonal antibody for INI1/hSNF5/BAF47

  Harada, A., Hayashi, M., Kuniyoshi, Y., Semba, Y., Sugahara, S., Tachibana, T., Ohkawa, Y. & Fujita, M., Feb 1 2014, In: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 33, 1, p. 49-51 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Antibodies 100%
  • Cellular Differentiation 100%
  • Western Blot 100%
  • Monoclonal Antibody 100%
  • Gene Expression 50%